• ページ数 : 396頁
  • 書籍発行日 : 2017年6月
  • 電子版発売日 : 2019年7月31日
ポイント : 1620 pt (6%)



Esophageal diseases have recently become a focus of clinical interest, especially in view of the increase in the number of cases of Barrett’s esophagus and Barrett’s carcinoma. This book presents a comprehensive description of the esophagus based on many works published in English as well as in Japanese. Topics range from the embryology and structure of the esophagus, to benign diseases and various esophageal infections, to esophageal malignancies. The numerous beautiful color illustrations of pathologic investigation using techniques such as cytology, immunohistochemistry, and electron microscopy, as well as the large number of endoscopic images provided in the book make readers immediately aware of its clinical relevance. In this third edition, many new images have been added, as well as details of recent advances in knowledge about Barrett’s esophagus and Barrett’s carcinoma. Images obtained by the new technique of endocytoscopy, allowing histopathologic diagnosis in situ, have also been included, and new references covering the last ten years have also been added and reviewed. Pathology of the Esophagus, Third Edition provides an invaluable source of information for pathologists, surgeons, and endoscopists.


Preface to the Third Edition

This third edition of Pathology of the Esophagus is published justafter my retirement and will be the last edition compiled by me.The opening page of this edition carries photos taken at theInternational Symposium: Tokyo Esophageal Research Day 2015,to commemorate the retirement of Dr. Kaiyo Takubo, and also onthe excursion to Nara and Kyoto after the Symposium. The followingpage also carries the text of the speech made by Professor HenryAppelman who proposed the toast at the party to mark myretirement.

Esophageal diseases have become a focus of clinical interest,especially in view of the rapid increase in the number of cases ofgastroesophageal reflux disease (GERD), Barrett's esophagus,and Barrett's carcinoma. This book presents a comprehensivedescription of the esophagus based on many works published inEnglish as well as in Japanese. Topics range from the embryologyand structure of the esophagus, to benign diseases and variousesophageal infections, to esophageal malignancies, includingBarrett's carcinoma. In the third edition, many new diagrams andhistologic and endoscopic images, approximately 80 figures in all,have been added. Photos that had appeared in the second editionhave been comprehensively improved, and various letters andarrows have been inserted in the illustrations with the aid of myphototechnologist colleague, Mr. Yoshihiro Fujita, to aid understandingof the explanations.

Images obtained by the new techniques of endocytoscopy,allowing histopathologic diagnosis in situ, and magnifying endoscopyhave been included, and new references covering the last10 years have also been added and reviewed. This edition providesa valuable source of information for pathologists, researchers,surgeons,and practicing endoscopists.

For this edition, specialists from all over the world generously provided not only specimens obtained by resection and biopsy butalso endoscopic images. These contributors are gratefully acknowledgedby name in the book. Among them, I am particularly gratefulto Dr. Miwako Arima, Department of Gastroenterology, SaitamaCancer Center Hospital, for supplying many beautiful endoscopicimages; Dr. Yoichi Kumagai, Department of Surgery, Saitama Medical University, for supplying many clear endocyotoscopyimages; and Dr. Junko Aida, Research Team for GeriatricPathology, Tokyo Metropolitan Institute of Gerontology, for providingmany histologic images for this edition. I also wish to thankDrs Ken‐ichi Nakamura, Naotaka Izumiyama‐Shimomura, YokoMatsuda, and Tomio Arai, members of the Research Team forGeriatric Pathology, Tokyo Metropolitan Institute of Gerontology,and Department of Pathology, Tokyo Metropolitan GeriatricHospital, for their help in preparing the manuscript.

The publication of the book was supported in part by FukushōjiBuddhist Temple, Kita‐ku, Tokyo, where I serve as the head priest,and many temple members contributed generously to thepublicationcost. Many copies of the first and second editions weredonated to medical doctors and universities throughout the world,and a considerable number of copies of this edition will also bedonated to Asian and African countries.

I retain copyright of the third edition, with the intention oftransferring it at no cost to a young pathologist in the near future,in the expectation that he or she will take responsibility forpublishingthe fourth, fifth, and further editions, and subsequentlyalso hand over the copyright without payment to a third doctor.In this way, it is my sincere expectation that new editions willcontinueto be published for a long time to come.

Kaiyo Takubo
Tokyo, March 1, 2016


Preface to the Third Edition

Preface to the Second Edition

Preface to the First Edition


Chapter1 Embryology and Developmental Anomalies of the Esophagus

1.1.Embryology of the Esophagus

1.2.Developmental Anomalie

Chapter2 Structure of the Esophagus

2.1.Anatomy of the Esophagus

2.2.Histology, Cytology, and Electron Microscopy of the Normal Esophagus

Chapter3 Vascular Disorders of the Esophagus

3.1.Esophageal Varices

3.2.Dieulafoy's Lesion of the Esophagus

Chapter4 Achalasia and Esophageal Motor Dysfunction


4.2.Secondary Achalasia

4.3.Diffuse Esophageal Spasm, Nutcracker Esophagus, and Hypertensive Lower Esophageal Sphincter

4.4.Alcoholic Neuropathy and Deterioration of Esophageal Peristalsis

4.5.Allgrove's Syndrome

4.6.Aging and Changes in the Nerve Plexus and Smooth Muscle

Chapter5 Infective Esophagitis

5.1.Viral Esophagitis

5.2.Fungal Esophagitis

5.3.Bacterial Esophagitis


5.5.Other Infections

Chapter6 Esophageal Manifestations of Collagen Vascular and Other Systemic Diseases

6.1.Progressive Systemic Sclerosis

6.2.Polymyositis, Dermatomyositis, Systemic Lupus Erythematosus, and Rheumatoid Arthritis

6.3.Sjögren's Syndrome

6.4.Idiopathic Eosinophilic Esophagitis

6.5.Lymphocytic Esophagitis

6.6.Skin Disorders

6.7.Graft‐Versus‐Host Disease

6.8.Behçet's Disease

6.9.Crohn's Disease


6.11.Ulcerative Colitis


6.13.Parkinson's Disease

6.14.Ceroidosis (Brown Bowel Syndrome)

6.15.Myasthenia Gravis

6.16.Myotonic Dystrophy

6.17.Hyperthyroidism and Hypothyroidis



6.20.Diabetes Mellitus

6.21.Wegener's Granulomatosis

6.22.Hepatolenticular Degeneration (Wilson's Disease)

Chapter7 Esophagitis and Esophageal Ulcer

7.1.Gastroesophageal Reflux Disease, Reflux Esophagitis, and Esophageal Ulcer

7.2.Corrosive Esophagitis

7.3.Iatrogenic Esophagitis

7.4.Exfoliative Esophagitis

7.5.Decubital Ulcer

7.6.Acute Necrotizing Esophagitis, Black Esophagus

7.7.Esophageal Phlegmon

7.8.GERD, Esophagitis, and Barrett's Esophagus Caused by Food Stasis Resulting from Kyphosis

Chapter8 Other Nonneoplastic Disorders of the Esophagus

8.1.Thermal Burn

8.2.Frostbite of the Esophagus

8.3.Foreign Body

8.4.Spontaneous Rupture

8.5.Mallory-Weiss Syndrome

8.6.Intramural Hematoma


8.8.Esophageal Diverticula

8.9.Esophageal Webs

8.10.Lower Esophageal Ring (Schatzki's Ring)

8.11.Esophageal Mucosal Bridge

8.12.Aortoesophageal Fistula

8.13.Hairy Esophagus

8.14.Other Miscellaneous Disorders

Chapter9 Benign Epithelial Tumors and Tumor‐Like Conditions

9.1.Retention Cyst

9.2.Lymphoepithelial Cyst

9.3.Esophageal Acanthosis Nigricans

9.4.Esophageal Manifestations of Cowden's Disease(Multiple Hamartoma Syndrome)

9.5.Squamous Papillom

9.6.Hyperplastic Polyp of Ectopic Gastric Mucosa in the Cervical Esophagus


Chapter10 Benign Non‐epithelial Tumors and Tumor‐Like Conditions of the Esophagus

10.1.Xanthoma of the Esophagus

10.2.Reflux Gastroesophageal Polyp and Inflammatory Reflux Polyp

10.3.Inflammatory Fibroid Polyp, Inflammatory Fibrous Polyp, and Inflammatory Pseudotumor

10.4.Pyogenic Granuloma of the Esophagus

10.5.Fibrovascular Polyp

10.6.Hamartomatous Polyp

10.7.Pseudomalignant Erosive and Ulcerative Lesion


10.9.Diffuse Leiomyomatosis of the Esophagus and Idiopathic Muscular Hypertroph




10.13.Granular Cell Tumor

10.14.Adult Rhabdomyoma


10.16.Glomus Tumor

10.17.Neurogenic Tumors

10.18. Calcifying Fibrous Pseudotumor

Chapter11 Classification and Stage of Malignant Neoplasms of the Esophagus

11.1.Location of Tumors Reported in Japan

11.2.Macroscopic Classification of Malignant Esophageal Neoplasms

11.3.Histologic Classification of Esophageal Neoplasms

11.4.Histological Subclassification of Invasion Depth by Superficial Carcinoma

11.5.Histological Staging of Malignant Esophageal Neoplasms

11.6.Esophageal Carcinoma in Children and Adolescents

Chapter12 Squamous Epithelial Dysplasia and Squamous Cell Carcinoma

12.1.Squamous Epithelial Dysplasia

12.2.Squamous Cell Carcinoma

12.3.Endocytoscopic Observation of Squamous Epithelium and Squamous Cell Carcinoma of the Esophagus

12.4.Microvascular Pattern and Invasion Depth by Squamous Cell Carcinoma

Chapter13 Barrett's Esophagus and Primary Adenocarcinoma of the Esophagus

13.1.Barrett's Esophagus

13.2.Primary Adenocarcinoma of the Esophagus

Chapter14 Carcinomas Other Than Squamous Cell Carcinoma and Adenocarcinoma

14.1.Adenosquamous Carcinoma (Coexistence of Adenocarcinoma and Squamous Cell Carcinoma)

14.2.Mucoepidermoid Carcinoma

14.3.Adenoid Cystic Carcinoma

14.4.Undifferentiated Carcinoma

14.5.Basaloid Squamous Carcinoma and Basaloid Carcinoma

14.6.Other Tumor Types

Chapter15 Malignant Non-epithelial Tumors of the Esophagus


15.2.Non‐Hodgkin's Lymphoma and Leukemia

15.3.Hodgkin's Disease

15.4.Extramedullary Plasmacytoma of the Esophagus

15.5.Malignant Granular Cell Tumor

15.6.Malignant Neurogenic Tumor


15.8.Angiogenic Sarcoma



15.11.Kaposi's Sarcoma

15.12.Synovial Sarcoma

15.13.Malignant Triton Tumor

15.14.Gastrointestinal Stromal Tumor


15.16.Malignant Rhabdoid Tumor

15.17.Extraskeletal Ewing's Sarcoma

15.18.Histiocytic Sarcoma

15.19.Malignant Glomus Tumor of the Esophagus

15.20.Epithelioid sarcoma

Chapter16 Carcinosarcoma and Pseudosarcoma

16.1.Carcinosarcoma and Pseudosarcoma

16.2.Macroscopic Features

16.3.Microscopic Features

16.4.Cytological Features

16.5.Ultrastructural Features

Chapter17 Malignant Melanoma and Related Entities

17.1.Primary Malignant Melanoma of the Esophagus

17.2.Metastatic Melanoma

17.3.Anthracosis of the Esophagus

Chapter18 Metastatic Carcinoma of the Esophagus

Chapter19 Handling of Surgically and Endoscopically Resected Specimens

19.1.Surgically Resected Specimens

19.2.Endoscopically Resected Specimens

Additional Readings



  • 対応
  • 一部対応
  • 未対応
  • 全文・
  • 目次・
  • PCブラウザ閲覧
  • メモ・付箋
  • PubMed
  • 動画再生
  • 音声再生
  • 今日の治療薬リンク
  • イヤーノートリンク
  • 南山堂医学
  • 対応
  • 一部対応
  • 未対応


  • ios icon

    iOS 10.0 以降



  • android icon

    AndroidOS 5.0 以降



  • コンテンツのインストールにあたり、無線LANへの接続環境が必要です(3G回線によるインストールも可能ですが、データ量の多い通信のため、通信料が高額となりますので、無線LANを推奨しております)。
  • コンテンツの使用にあたり、M2Plus Launcherが必要です。 導入方法の詳細はこちら
  • Appleロゴは、Apple Inc.の商標です。
  • Androidロゴは Google LLC の商標です。


  • ISBN:9784939028359
  • ページ数:396頁
  • 書籍発行日:2017年6月
  • 電子版発売日:2019年7月31日
  • 判:A4変型
  • 種別:eBook版 → 詳細はこちら
  • 同時利用可能端末数:3





※コンテンツの使用にあたり、 電子書籍(iOS/iPhoneOS/AndroidOS)が必要です。